Selected Methods of Pharmaceutical Technology
Section outline
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Differential scan calorimetry (DSC)
Determination of melting point of suppository bases and suppositories
Determination of glass transition temperature of polymers and the effect of plasticization
Evaluation of solid dispersions by DSCPycnometric density of solids, porosimetry
Determination of tablet´s excipients density
Determination of tableting materials density
Determination of density and porosity of tablets in dependence on compression pressureDetermination of surface tension of liquids
Determination of surface tension of water
Determination of surface tension of surfactant solutions (cationic, anionic and nonionic)Rheological evaluation of pharmaceutical preparations
Analysis of rheogram by appropriate models
Characterization of semi-solid preparations by Herschel-Bulkely model (coefficient of consistency and flow behaviour)
Thixotropy characterization of the pharmaceutical preparations
Influence of the pharmaceutical preparations composition and technology of compounding on rheological characteristicsSpray drying
Influence of process parameters on the quality of a dried product
Evaluation of the spray dried productEvaluation of the compressibility of tabletting materials and the effect of lubricants. 3D printing of tablets.
Evaluation of the energetic profile of dry binders and directly compressible tabletting materials
Evaluation of the compactibility of dry binders and directly compressible tabletting materials by tensile strength of tablets
Evaluation of the lubricant effect in tabletting materials
Selective laser sintering as a method of tablet preparationDissolution tests
Determination of active ingredients dissolution profile released from prolonged release tablets
Comparison of basket, paddle and flow- through cell dissolution methods
Influence of dissolution test´s settings on dissolution profiles -
The course will enable students interested in working in the pharmaceutical industry to gain deeper theoretical and practical knowledge in the field of some specialized manufacturing and control processes of pharmaceutical technology. The methods included in the teaching are connected with the evaluation of raw materials, preparation of intermediates or production of final medicinal products and their evaluation. The focus of the course is on other courses that allow students to profile industrial pharmacy.
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